What is MBEH Cream?
MBEH stands for Monobenzyl Ether of Hydroquinone — the chemical name for monobenzone. MBEH cream is pharmaceutical-grade monobenzone topical cream used for permanent depigmentation in vitiligo patients.
MBEH (monobenzone) is classified as the most potent depigmenting agent available, and has been FDA-approved since 1952 for permanent depigmentation of extensive vitiligo.
MBEH / Monobenzone — Same Product
The following terms all refer to the same pharmaceutical product:
- MBEH cream — chemical abbreviation
- Monobenzone cream — generic pharmaceutical name
- Monobenzyl ether of hydroquinone cream — full chemical name
- Benoquin cream — discontinued brand name
- Monozan cream — Behvazan Pharmaceutical brand name
How MBEH Works
MBEH causes free-radical-mediated destruction of melanocytes and inhibits tyrosinase activity — permanently removing pigment from treated skin areas. The effect is irreversible as destroyed melanocytes cannot regenerate.
Buy MBEH Cream Online
Our monobenzone (MBEH) cream is available in 20% and 40% concentrations from $12 per tube with worldwide shipping via UPS and FedEx. Contact us on WhatsApp for pricing.
Benefits of MBEH Cream
For patients with extensive vitiligo who have decided on permanent depigmentation, MBEH cream offers several clinically meaningful benefits beyond simple cosmetic change:
- Uniform skin appearance: Eliminates the visual contrast between remaining pigmented skin and existing vitiligo patches, creating one consistent tone
- Permanent result: Unlike hydroquinone or other suppressive agents, the depigmentation achieved does not reverse once treatment is complete
- FDA-recognised mechanism: Built on 70+ years of clinical use of monobenzone as the approved active ingredient for this specific indication
- Flexible strength options: Available at 20%, 40%, and 60% concentrations to match individual tolerance and treatment goals
- Documented quality: Every batch is accompanied by a Certificate of Analysis confirming active ingredient concentration and manufacturing standards
- Psychological relief: Many patients report a significant improvement in confidence and quality of life once a uniform skin tone is achieved
Ingredients
MBEH Cream contains monobenzone (monobenzyl ether of hydroquinone, MBEH) as its sole active pharmaceutical ingredient, formulated in a water-washable cream base.
| Component | Function |
|---|---|
| Monobenzone (MBEH) 20g per 100g | Active depigmenting agent |
| Purified water USP | Base carrier |
| Cetyl alcohol NF | Emollient/thickener |
| Propylene glycol USP | Humectant/penetration aid |
| Sodium lauryl sulfate NF | Emulsifier |
Formulation is consistent with the original Benoquin Cream 20% USP composition. Always check your specific batch's Certificate of Analysis for exact excipient details.
Directions for Use
- Cleanse: Wash the treatment area with mild soap and lukewarm water; pat completely dry
- Apply thinly: Use a pea-sized amount per hand-sized area — a thin, even layer only
- Target correctly: Apply only to normally pigmented skin, not to existing vitiligo patches (which have no melanocytes to affect)
- Massage in: Gently rub until absorbed; do not apply a second layer
- Wash hands immediately: Within 2 minutes of application to avoid unintended depigmentation of palms
- Apply sunscreen: SPF 50+ broad-spectrum, 10-15 minutes after the cream is absorbed
- Repeat twice daily: Morning and evening, approximately 12 hours apart, without skipping applications
Storage Instructions
- Store below 25°C in a cool, dry place away from direct sunlight
- Do not refrigerate
- Keep the tube tightly closed when not in use
- Keep out of reach of children
- In hot climates (including GCC summer conditions), store in an air-conditioned room — never in a car or un-cooled space
- Shelf life is 2 years from the manufacturing date shown on the packaging; use within 12 months of first opening
Warnings & Precautions
- Not intended for cosmetic skin lightening, melasma, or age spots — consult a dermatologist about hydroquinone-based alternatives for these conditions
- Not recommended during pregnancy or breastfeeding without explicit physician guidance
- Not routinely recommended for children under 12 without specialist supervision
- Avoid contact with eyes, lips, and mucous membranes
- Depigmented skin becomes permanently sun-sensitive — lifelong SPF 50+ sunscreen is mandatory on treated areas
- Stop use and consult a dermatologist if you notice blue-black skin discoloration (a rare condition called exogenous ochronosis) or severe allergic reaction
- Wash hands thoroughly immediately after every application to prevent unintended depigmentation
Shipping Information
MBEH Cream ships worldwide from GulfDermaCare with free UPS or FedEx Express shipping on every order:
| Destination | Delivery Time |
|---|---|
| Saudi Arabia | 3-6 business days |
| UAE | 3-5 business days |
| Qatar, Kuwait, Bahrain | 4-6 business days |
| Oman | 4-7 business days |
| USA | 5-8 business days |
Every order includes a Certificate of Analysis, commercial invoice, and packing list to support customs clearance. Full details on our Shipping Policy page.
Return & Refund Policy
We accept returns of unopened, unused MBEH cream within 7 days of delivery. If your order arrives damaged or incorrect, we arrange a free replacement at no cost to you. Full terms are available on our Return Policy page.
Who Should Consider MBEH Cream
MBEH cream is formulated for patients with extensive vitiligo — generally 50% or more of body surface area — who have either exhausted repigmentation options or made an informed decision to pursue permanent depigmentation as their treatment path.
It is not a first-line treatment for limited or localized vitiligo, where repigmentation therapies (topical steroids, NB-UVB phototherapy, calcineurin inhibitors) still offer a realistic chance of restoring natural pigment in affected areas.
Given the permanent nature of MBEH's effect, a thorough conversation with a qualified dermatologist — covering realistic timelines, expected side effects, and the lifelong sun protection commitment — is strongly recommended before starting treatment.